RNA Details
Disease Name
heart failure
Tissue
heart
RNA Symbol
mir-21a
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
PCR; immunohistochemistry etc.
Target
SPROUTY-1
Pathway
PI3K-AKT SIGNALING PATHWAY
PubMed ID
Title
Role for MicroRNA-21 in Atrial Profibrillatory Fibrotic Remodeling Associated With Experimental Postinfarction Heart Failure
Year
2012
Function
"Atrial miR-21 knockdown suppresses atrial fibrosis(AF) and AF promotion, implicating miR-21 as an important signaling molecule for the AF substrate and pointing to miR-21 as a potential target for molecular interventions designed to prevent AF."